Tirzepatide Side Effects You Should Know

Tirzepatide has become a popular treatment option for Canadians. It is an injectable drug that goes by two different brand names. One form of this drug, Mounjaro, is authorized for sale by Health Canada to manage type 2 diabetes while its counterpart, Zepbound, has been indicated for long-term weight management. Both use the same tirzepatide compound and work the same way on the body.

By educating yourself about tirzepatide, you can better assess the benefits and risks of using this medication. Let's explore the side effects you should know about in order to make a well-informed decision on whether this medication is a good choice for you. 

What are the side effects of tirzepatide ? 

Tirzepatide is an injectable medication that works by activating GIP and GLP-1 receptors in the body to help improve blood sugar levels. Tirzepatide also slows down digestion, increases fullness and reduces appetite, helping to decrease calorie intake and reduce body weight.

Some of the most common tirzepatide side effects include:

• Nausea
• Vomiting
• Diarrhea
• Constipation
• Stomach pain
• Feeling weak or tired
• Acid reflux

Other side effects that may occur include belching, bloating of the stomach, gas (flatulence), increased heart rate or indigestion. 

Some patients have reported experiencing injection site reactions, such as pain, bruising, irritation, itching, and rash. These reactions should go away within a few days and be localized to the injection site only. If they spread beyond the injection site, then you should stop using the medication and talk to your healthcare practitioner or seek-in person care.

Who should not take tirzepatide?

Tirzepatide cannot be used in patients with type 1 diabetes, a personal or family history of medullary thyroid carcinoma (MTC) or a personal history of Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). It is not known if tirzepatide can be used safely                                                                           in people who have had pancreatitis and so you should discuss this with your healthcare practitioner. 

It’s also important to note that tirzepatide cannot be used in patients who are pregnant, breastfeeding, or trying to conceive. Tirzepatide may make oral birth control less effective. Patients who are currently using oral contraceptives (birth control pills) should let their healthcare practitioner know, as they may recommend alternative birth control methods or use of a back-up method.

While tirzepatide can be an effective medication, it's important to give your healthcare practitioner a detailed medical history so they can help find a treatment option that is safe and right for you.

How long do the side effects of tirzepatide last? 

The length of time and the severity of the side effects of tirzepatide vary from person to person. Many people experience short-term side effects, like nausea, vomiting, constipation or diarrhea for several days or weeks after starting treatment. These symptoms should resolve as your body adjusts to the medication. If your side effects last longer or become moderate, frequent, or unmanageable, message your healthcare practitioner to have the symptoms assessed. Side effects may return temporarily when the medication dose is increased.

Severe side effects require immediate in-person medical attention at your local emergency department or urgent care centre. In some cases, individuals may need to stop taking tirzepatide altogether.

Tips for managing side effects

The most common side effects of tirzepatide are gastrointestinal in nature (nausea, vomiting, constipation, diarrhea, and acid reflux). There are a few strategies that may help to manage them:

• Eating smaller, more frequent meals
• Eating slowly
• Drinking plenty of water
• Avoiding fatty or sweet foods
• Eating blander foods like toast, crackers, or rice

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Whether mild or moderate, you should speak with a healthcare practitioner if you're experiencing any side effects while taking tirzepatide (severe, significant or persistent side effects require immediate in-person care). They can guide you through how to manage your symptoms, how long they may last, and help ensure your overall health and well-being.

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This information does not replace medical advice. Any questions you have about your treatment are best discussed directly with your healthcare practitioner.

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