Patient Info

Tadalafil vs. Sildenafil: What’s the Difference?

Key Takeaways
  • Tadalafil, brand name Cialis, can last up to 36 hours and can be taken daily or as-needed. 
  • Sildenafil, brand name Viagra, lasts 4-6 hours and is best taken on an empty stomach. 
  • Oral strips dissolve quickly and have a faster onset. It can be more convenient or discreet compared to oral tablets.

Sildenafil (brand name Viagra) and tadalafil (brand name Cialis) are two common erectile dysfunction (ED) medications. They typically come in tablet or oral strip form. Both these medications are PDE5 inhibitors and work by increasing blood flow to help achieve and maintain an erection. These medications do not increase sexual desire and require sexual stimulation to be effective. 

Choosing the right treatment is important. Some key differences between the available options include:

  • Onset of action
  • Duration of effect
  • Dosing options
  • Cost

These factors help you and your healthcare practitioner decide which treatment best fits your needs.

The table below summarizes the differences between the different medications available:

Tadalafil Cialis Tadalafil Oral Strips Sildenafil Viagra Viagra Oral Strips
Active ingredient Tadalafil Tadalafil Tadalafil Sildenafil Sildenafil Sildenafil
Onset of action ~30-60 minutes ~30-60 minutes ~15-30 minutes ~30-60 minutes ~30-60 minutes ~15-30 minutes
Duration of effect Up to 36 hours Up to 36 hours Up to 36 hours 4-6 hours 4-6 hours 4-6 hours
Common tablet doses 2.5-20mg 2.5-20mg 20mg 25-100mg 50-100mg 50mg
Daily dosing option Yes (2.5mg-5mg daily) Yes (2.5mg-5mg daily) No No No No
As-needed dosing 10-20mg 10-20mg 20mg 50-100mg 50-100mg 50-100mg
How it’s taken Swallowed with water Swallowed with water Dissolves on tongue Swallowed with water Swallowed with water Dissolves on tongue
Food restrictions None None None Best on an empty stomach Best on an empty stomach Best on an empty stomach

Felix also offers ED treatment starter bundles so that you try different options to determine what works best for you, whether you prefer daily use or as-needed.

  • ED Daily Combo Pack: sildenafil 25mg, sildenafil 50mg, tadalafil 5mg x 5, tadalafil oral strip
  • ED As-Needed Combo Pack: sildenafil 25mg, sildenafil 50mg, tadalafil 10mg, tadalafil oral stirp

Pricing

Cost of Viagra:

Dosage Quantity Potential cost*
50mg 4 tablets Starts at $42
100mg 4 tablets Starts at $44

Cost of sildenafil:

Dosage Quantity Potential cost*
25mg 4 tablets Starts at $40
50mg 4 tablets Starts at $42
100mg 4 tablets Starts at $44

Cost of Viagra oral strips:

Dosage Quantity Potential cost*
25mg 1 oral strip Starts at $12

Cost of Cialis:

Dosage Quantity Potential cost*
2.5mg 28 tablets Starts at $177
5mg 4 tablets Starts at $25
10mg 4 tablets Starts at $82
20mg 4 tablets Starts at $85

Cost of tadalafil:

Dosage Quantity Potential cost*
2.5mg 28 tablets Starts at $122
5mg 4 tablets Starts at $17
10mg 4 tablets Starts at $57
20mg 4 tablets Starts at $59

Cost of tadalafil oral strips:

Dosage Quantity Potential cost*
20mg 1 strip Starts at $14

*Prices shown do not reflect provincial or private insurance coverage and may vary by province and pharmacy. 

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References

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